FIELD: biotechnology, pharmacology, medicine.
SUBSTANCE: DNA sequence encoding of new kind of human serine protease (DPRP-2), is cloned and characterized, wherein said DPRP-2 is cognate to dipeptidyl oligopeptidase IV and hase gomology wherewith of 39 % determined using amino acid sequence. By using of recombinant DNA technologe recombinant form of DPRP-2 is obtained and kinetic properties of new enzyme (substrate specifity, Km values, activity inhibitors, etc.) are investigated.
EFFECT: new means for screening and development of new therapeutic agents for treatment of various deceases in human.
4 cl, 7 dwg, 7 ex
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