FIELD: biotechnology.
SUBSTANCE: invention relates to water soluble polypeptides (SEQ ID NO.12) and (SEQ ID NO.7), derived from full-length tryptophanyl-tRNA-synthetase and having angiostatic activity in relation to eye neovasculatisation. Also disclosed are polynucleotides, encoding truncated polypeptide forms (SEQ ID NO.12) and (SEQ ID NO.7), and E.coli cell, expressing abovementioned polypeptides. Said polypeptides are useful in injecting angiostatic composition and kit for inhibiting of eye neovasculatisation.
EFFECT: polypeptides having non-immunogenic angiogenic properties.
22 cl, 5 dwg, 2 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DISEASE-RELATED PROTEIN | 2002 |
|
RU2384586C2 |
| CODON-OPTIMIZED COMPLEMENT FACTOR I | 2019 |
|
RU2824048C2 |
| SYNP161, PROMOTER FOR SPECIFIC GENE EXPRESSION IN ROD PHOTORECEPTORS | 2016 |
|
RU2758211C2 |
| METHOD OF TREATING RETINOPATHY IN PREMATURITY AND RELATED RETINOPATHIC DISEASES | 2006 |
|
RU2403906C2 |
| COMPLEMENT FACTOR I AND COMPLEMENT FACTOR I COFACTOR, VECTORS ENCODING THEM AND USE FOR THERAPEUTIC PURPOSES | 2019 |
|
RU2809247C2 |
| NEW ISOFORMS OF VASCULAR ENDOTHELIAL CELL GROWTH INHIBITOR | 2002 |
|
RU2316591C2 |
| COMPOSITIONS AND METHODS OF TREATING AND PREVENTING MACULAR DEGENERATION | 2015 |
|
RU2703145C2 |
| SYNP198, PROMOTOR FOR SPECIFIC GENE EXPRESSION IN RETINAL GANGLION CELLS SELECTIVE RELATIVELY TO DIRECTION | 2017 |
|
RU2766353C2 |
| HEMOPOIETIC STEM CELLS POPULATION AND ITS APPLYING | 2003 |
|
RU2331669C2 |
| PROMOTOR SPECIFIC RELATIVELY TO CELLS OF APE RETINAL PIGMENT EPITHELIUM | 2018 |
|
RU2773940C2 |
