Show metadata Hide metadata

(19)

(11)

2 663 846

(13)

(51)

IPC

C07D498/14(2006-01-01)

A61K31/4245(2006-01-01)

(21) (22)

Application

2017136002, 2017-10-10

(24)

Start date

2017-10-10

(22)

Actual filing date

2017-10-10

(45)

Published

2018-08-10

(72)

Inventor

Lotorev Dmitrij SergeevichBrylev Maksim IgorevichAlekseev Aleksej AnatolevichKorolev Vyacheslav LeonidovichMerkulova Natalya LeonidovnaKudryavtseva Tatyana Nikolaevna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Universitet"

METHOD FOR PRODUCTION OF N-CARBETHOXYMETHYLIMIDAZO[4,5-E]BENZO[1,2-C;3,4-C']DIFUROXANE Russian patent published in 2018 - IPC C07D498/14 A61K31/4245

Abstract RU 2663846 C1

FIELD: chemistry.

SUBSTANCE: invention relates to process for preparation of N-carbethoxymethylimidazo[4,5-e]benzo[1,2-c;3,4-c']difuroxan – an effective inhibitor of ADP-induced platelet aggregation. New method for preparation of N-carbethoxymethylimidazo[4,5-e]benzo[1,2-c;3,4-c']difuroxane, characterized in that the alkylation of imidazo[4,5-e]benzo[1,2-c;3,4-c']difuroxane with ethyl bromoacetate is carried out in dimethylformamide.

EFFECT: method allows to simplify the method of production and to increase the yield of the desired product.

1 cl, 1 ex

Similar patents RU2663846C1

Title	Year	Author	Number
METHOD OF PRODUCING N-CARBETHOXYMETHYL-C-METHYLIMIDAZO[4,5-E]BENZO[1,2-C;3,4-C']DIFUROXANE	2020	Korolev Vyacheslav Leonidovich Merkulova Natalya Leonidovna Lotorev Dmitrij Sergeevich Kuznetsov Pavel Evgenevich Maksimov Vladimir Alekseevich Kudryavtseva Tatyana Nikolaevna	RU2725631C1
METHOD FOR PRODUCING N-CARBETOXIMETHYLIMIDEAZO[4,5-e]BENZO[1,2-c;3,4-c']DYFUROXANE	2016	Korolev Vyacheslav Leonidovich Toporov Vladislav Vladimirovich Danilenko Vitalij Mikhajlovich Ivshin Viktor Pavlovich Lotorev Dmitrij Sergeevich Pavlova Lyudmila Anatolevna	RU2618230C1
METHOD OF PRODUCING N-CYANOMETHYLIMIDAZO[4,5-E]BENZO[1,2-C;3,4-C']DIFUROXANE	2019	Korolev Vyacheslav Leonidovich Merkulova Natalya Leonidovna Lotorev Dmitrij Sergeevich Pivina Tatyana Stepanovna Kuznetsov Pavel Evgenevich Maksimov Vladimir Alekseevich Kudryavtseva Tatyana Nikolaevna	RU2707296C1
METHOD OF PRODUCING N-ALLYLIMIDAZO[4,5-E]BENZO[1,2-C;3,4-C']DIFUROXANE	2019	Korolev Vyacheslav Leonidovich Merkulova Natalya Leonidovna Lotorev Dmitrij Sergeevich Kuznetsov Pavel Evgenevich Maksimov Vladimir Alekseevich Kudryavtseva Tatyana Nikolaevna	RU2718905C1
METHOD OF OBTAINING C-NITROIMIDAZO[4,5-E]BENZO[1,2-C;3,4-C']DIFUROXANE	2018	Korolev Vyacheslav Leonidovich Merkulova Natalya Leonidovna Danilenko Vitalij Mikhajlovich Pivina Tatyana Stepanovna Lotorev Dmitrij Sergeevich Kudryavtseva Tatyana Nikolaevna	RU2675159C1
METHOD OF PRODUCING C-NITROIMIDAZO[4,5-E]BENZO[1,2-C;3,4-C']DIFUROXANE	2019	Korolev Vyacheslav Leonidovich Merkulova Natalya Leonidovna Danilenko Vitalij Mikhajlovich Pivina Tatyana Stepanovna Lotorev Dmitrij Sergeevich Kudryavtseva Tatyana Nikolaevna	RU2700931C1
METHOD OF PRODUCING C-HYDROXYMETHYLIMIDAZO[4,5-E]BENZO[1,2-C; 3,4-C']DIFUROXANE	2019	Korolev Vyacheslav Leonidovich Merkulova Natalya Leonidovna Danilenko Vitalij Mikhajlovich Pivina Tatyana Stepanovna Lotorev Dmitrij Sergeevich Kudryavtseva Tatyana Nikolaevna	RU2692680C1
N-CARBOXYMETHYLIMIDAZO[4,5-e]BENZO[1,2-c;3,4-c']DIFUROXANE	2014	Korolev Vjacheslav Leonidovich Toporov Vladislav Vladimirovich Danilenko Vitalij Mikhajlovich Ivshin Viktor Pavlovich Alekseev Aleksej Anatol'Evich Pavlova Ljudmila Anatol'Evna	RU2544547C1
THROMBOCYTE AGGREGATION-INHIBITING HETEROMERIC PEPTIDES BASED ON IMIDAZO[4,5-e]BENZO[1,2-c;3,4-c']DIFUROXANE	2014	Alekseev Aleksej Anatol'Evich Brylev Maksim Igorevich Korolev Vjacheslav Leonidovich Lotorev Dmitrij Sergeevich Lizunov Anton Jur'Evich Pavlova Ljudmila Anatol'Evna Belushkina Natal'Ja Nikolaevna	RU2550223C1
THROMBOCYTE AGGREGATION-INHIBITING N-CARB(ARGINYL)OXYMETHYLIMIDAZO[4,5-e]BENZO[1,2-c;3,4-c']DIFUROXANE	2014	Alekseev Aleksej Anatol'Evich Brylev Maksim Igorevich Korolev Vjacheslav Leonidovich Lotorev Dmitrij Sergeevich Batuev Evgenij Andreevich Pavlova Ljudmila Anatol'Evna Belushkina Natal'Ja Nikolaevna	RU2549355C1

RU 2 663 846 C1

Authors

Lotorev Dmitrij Sergeevich

Brylev Maksim Igorevich

Alekseev Aleksej Anatolevich

Korolev Vyacheslav Leonidovich

Merkulova Natalya Leonidovna

Kudryavtseva Tatyana Nikolaevna

Dates

2018-08-10—Published

2017-10-10—Filed