Show metadata Hide metadata

(19)

(11)

2 664 463

(13)

(51)

IPC

C07K16/28(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

C12N5/10(2006-01-01)

A61K39/395(2006-01-01)

A61K47/68(2017-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2015130605, 2013-12-23

(24)

Start date

2013-12-23

(22)

Actual filing date

2013-12-23

(45)

Published

2018-08-17

(72)

Inventor

Anderson MarkVan TszeiTakur ArchanaChao DebraKhsiekh Chung-MingChzhan TsyanRejlli Edvard B.Didzhammarino Enriko L.Longeneker Kenton L.Dzhadzh Rassell A.Egan Devid A.Khatchins Charlz V.

(73)

Holder

Ebbvi Ink.

PROLACTIN RECEPTOR BINDING PROTEINS AND THEIR USE Russian patent published in 2018 - IPC C07K16/28 C12N15/13 C12N15/63 C12N5/10 A61K39/395 A61K47/68 A61P35/00

Abstract RU 2664463 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to immunology. Antibody capable of binding prolactin receptor (PRLR) is proposed. Nucleic acid encoding it, an expression vector and a host cell for producing said antibody are also described. In addition, a pharmaceutical composition comprising said antibody and an antibody-drug conjugate are considered.

EFFECT: antibody of the present invention is useful for detecting PRLR and for inhibiting PRLR activity in a human suffering from a disorder in which PRLR activity is detrimental.

11 cl, 11 dwg, 26 tbl, 10 ex

Similar patents RU2664463C2

Title	Year	Author	Number
COMBINATION CANCER THERAPIES TARGETTING CD38 AND TGF-BETA	2019	Adrian, Francisco Gregory, Richard C. Shapiro, Gary Van De Velde, Helgi	RU2808632C2
ANTIBODIES TO CD40 AND METHODS OF USE THEREOF	2016	Benatuil Lorentso Ardzhiriadi Mariya A. Makraj Bredford L. Khsiekh Chung-Ming Igan Devid A. Kharlan Dzhon E. Dzhadzh Rassel A. Van Zhuj Kingzberi Dzhillian A.	RU2715597C2
ANTIBODIES TARGETING A RECEPTOR BOUND TO G-PROTEINS, AND METHODS FOR USE THEREOF	2015	Liu, Cheng Smith, Eric, L. Brentjens, Renier, J.	RU2725819C2
ANTIBODIES TO GLUCAGON RECEPTOR AND THEREOF APPLICATION	2009	Li, Eunkiung Seo, Seong-Kiung Kim, Tae-Seong	RU2562110C2
METHOD OF PURIFICATION FOR REMOVING TYROSINE SULPHATED ANTIBODIES VARIANTS, PURIFIED COMPOSITIONS	2017	Chzhao, Tszya Rajos, Sandra Shyussler, Svetlana Dukleska	RU2793400C2
INTERLEUKIN-13-BINDING PROTEINS	2016	Vu Chenbin Dikson Richard V. Belk Dzhonatan P. In Khua Ardzhiriadi Mariya A. Kaff Kerolin A. Khinton Pol R. Kumar Shankar Melim Terri L. Chen Yan	RU2650767C2
INTERLEUKIN-13-BINDING PROTEINS	2012	Vu Chenbin Dikson Richard V. Belk Dzhonatan P. In Khua Ardzhiriadi Marija A. Kaff Kerolin A. Khinton Pol R. Kumar Shankar Melim Terri L. Chen Jan	RU2605327C2
INTERLEUKIN-13 BINDING PROTEINS	2007	Vu Chenbin Dikson Richard V. Belk Dzhonatan P. In Khua Ardzhiriadi Marija A. Kaff Kehrolin A. Khinton Pol R. Kumar Shankar Melim Terri L. Chehn' Jan'	RU2472807C2
ANTIBODIES TARGETING B-CELL MATURATION ANTIGEN AND METHODS OF THE USE THEREOF	2015	Liu, Cheng Smith, Eric, L. Brentjens, Renier, J.	RU2766094C2
MOLECULES THAT BIND BCMA AND USE OF SUCH MOLECULES	2019	Abujoub, Aida Blankenship, John Fleming, Tony Holmberg, Brian Hong, Connie Huang, Lu Lu, Haihui Granda, Brian Walter	RU2812322C2

RU 2 664 463 C2

Authors

Anderson Mark

Van Tszei

Takur Archana

Chao Debra

Khsiekh Chung-Ming

Chzhan Tsyan

Rejlli Edvard B.

Didzhammarino Enriko L.

Longeneker Kenton L.

Dzhadzh Rassell A.

Egan Devid A.

Khatchins Charlz V.

Dates

2018-08-17—Published

2013-12-23—Filed