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(19)

(11)

2 605 327

(13)

(51)

IPC

C07K16/24(2006-01-01)

A01H1/02(2006-01-01)

A01H1/08(2006-01-01)

C12N15/82(2006-01-01)

C07K14/415(2006-01-01)

(21) (22)

Application

2012142311/10, 2012-10-04

(24)

Start date

2007-09-07

(22)

Actual filing date

2012-10-04

(45)

Published

2016-12-20

(72)

Inventor

Vu ChenbinDikson Richard V.Belk Dzhonatan P.In KhuaArdzhiriadi Marija A.Kaff Kerolin A.Khinton Pol R.Kumar ShankarMelim Terri L.Chen Jan

(73)

Holder

Ebbvi Bakhamaz Ltd

INTERLEUKIN-13-BINDING PROTEINS Russian patent published in 2016 - IPC C07K16/24 A01H1/02 A01H1/08 C12N15/82 C07K14/415

Abstract RU 2605327 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry. Antibodies are disclosed, which are chimeric, CDR-transplanted and humanized antibodies with high affinity to hIL-13 and neutralizing activity of hIL-13 in vitro and in vivo. Method of obtaining and using antibodies according to invention is disclosed.

EFFECT: antibodies, or parts of antibodies under the invention can be used for detection of hIL-13 and for inhibiting hIL-13 activity, for example, in human suffering from violation, in which hIL-13 activity negatively affects patient's health.

36 cl, 23 tbl, 2 ex

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RU 2 605 327 C2

Authors

Vu Chenbin

Dikson Richard V.

Belk Dzhonatan P.

In Khua

Ardzhiriadi Marija A.

Kaff Kerolin A.

Khinton Pol R.

Kumar Shankar

Melim Terri L.

Chen Jan

Dates

2016-12-20—Published

2012-10-04—Filed