HETEROARYLCARBOXYLIC ACID ESTER DERIVATIVES Russian patent published in 2018 - IPC C07D333/40 C07D409/06 C07D409/12 A61K31/381 A61K31/397 A61K31/41 A61K31/44 A61P3/04 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I), wherein

where R¹ and R² are identical or different and each independently represents a C_1-4alkyl group; X is -OH or a group represented by formula (II) where R⁶ is a hydrogen atom; Ra and Rb are identical or different and each independently represents a hydrogen atom, carboxylC_1-8an alkyl group or a carboxyl group; ring A is an arene, C_3-6 heterocycle containing 1 to 4 heteroatoms selected from the group consisting of O and N, C_3-8cycloalkane ring or C_3-8cycloalkene ring, where said C_3-6 heterocycle, said C_3-8cycloalkane ring and said C_3-8cycloalkene ring can be further substituted with an oxo group, in addition to Ya and Yb; Ya is a hydrogen atom, a halogen atom, a carboxyl group, a hydroxyl group, C_1-3alkoxycarbonyl group, carboxylC_1-3alkyl group or a sulpho group; Yb is a hydrogen atom, a halogen atom, a carboxyl group, a hydroxyl group, C_1-3alkoxycarbonyl group, carboxylC_1-3alkyl group or C_1-3alkoxy group; p is 0 or 1; q is 1; and R⁷ represents hydrogen atom or halogen atom; or a pharmaceutically acceptable salt thereof.

EFFECT: invention is used as hyperglycemic inhibitors having a serine protease inhibitory action.

23 cl, 14 tbl, 9 ex, 2 dwg