THIOPHENE COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS Russian patent published in 2011 - IPC C07D409/12 C07D409/14 C07D413/14 A61K31/381 A61K31/4436 A61K31/42 A61P7/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula

,

where R¹ is a phenyl group (said phenyl group is substituted with one or more C_1-6alkyl groups, one C_1-3alkyl group (said C_1-3alkyl group is substituted with one or more halogen atoms), one C_1-3alkoxy group (said C_1-3alkoxy group is substituted with one or more halogen atoms) or one or more halogen atoms), R² is a C_1-3alkyl group, R³ is a phenyl group (said phenyl group is substituted with one or more substitutes selected from a group comprising halogen atoms or a (C=O)R^5' group (where R^5' is NR^6'R^7', (where R^6' is a hydrogen atom, and R^7' is a C_1-6alkyl group substituted with a hydroxyl group))), a thienyl group (said thienyl group is substituted with one or more substitutes selected from a group comprising hydrogen atoms and a (C=O)R⁵ group (where R⁵ is NR⁶R⁷ (where R⁶ is a hydrogen atom or a C_1-3alkyl group, and R⁷ is a C_1-6alkyl group (said C_1-6alkyl group can be substituted with one or more hydroxyl groups, one C_1-3alkoxy group or a 5-6-member aromatic heterocyclic group containing 1-2 heteroatoms selected from oxygen or nitrogen (where the 5-6-member aromatic heterocyclic group can be substituted with one or more C_1-3alkyl groups, one or more C_1-3alkoxy groups, and in case of a 5-6-member aromatic heterocyclic group containing one nitrogen atom, can be in be in form of N-oxides)), a pyridyl group, or overall NR⁶R⁷ is a nitrogen-containing heterocyclic group which is a 5-6-member hetero-monocyclic group which contains one or two nitrogen atoms and can additionally contain on oxygen atom (said nitrogen-containing heterocyclic group can be substituted with one or more hydrogen atoms, one or more C_1-6alkyl group, one or more hydroxyl groups)) or C_1-6alkyl group (said C_1-6alkyl group can be substituted with one or more halogen atoms and is substituted with one cyano group))), and R⁴ is a hydrogen atom or to a pharmaceutically acceptable salt of said compound. The invention also relates to a medicinal agent for preventing or treating diseases, in which activation of the thrombopoietin receptor is effective, based on said compounds.

EFFECT: obtaining novel compounds and agents based thereon, which can be used in medicine to increase the number of thrombocytes.

33 cl, 7 tbl, 43 ex