TRIAZOLOPYRIDINE COMPOUND AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR AND ERYTHROPOIETIN PRODUCTION INDUCER Russian patent published in 2015 - IPC C07D471/04 A61K31/437 A61P7/06 

FIELD: chemistry.

SUBSTANCE: invention relates to a triazolopyridine compound of general formula [I] or a pharmaceutically acceptable salt, where the partial structural formula: is a group represented by any of the following formulae: or R¹ is (1) a hydrogen atom, (2) C_1-6alkyl group, (3) phenyl group or (4) C_3-8cycloalkyl group; R² is (1) a hydrogen atom, (2) C_1-10alkyl group, (3) phenyl group, optionally substituted with identical or different 1-3 substitutes selected from the following groupB, (4) C_3-8cycloalkyl group, (5) C_3-8cycloalkenyl group, (6) thienyl group, optionally substituted with 1 substitute selected from halogen or C_1-6alkyl group, (7) phenyl-C_1-6alkyl group (wherein phenyl is optionally substituted with different or identical 1-2 substitutes selected from halogen, C_3-8cycloalkyl or halogen-C_1-6alkyl group) or (8) C_3-8cycloalkyl-C_1-6alkyl group; R³ is (1) a hydrogen atom, (2) a halogen atom, (3) C_1-6alkyl group, (4) phenyl group (6) phenyl-C_1-6alkyl group; and each of R⁴ and R⁵ are both hydrogen atoms or a group B: (a) a halogen atom, (b) C_1-6alkyl group, (c) C_3-8cycloalkyl group, (d) cyano group and (e) halogen-C_1-6alkyl group. The invention also relates to the specific compounds, a pharmaceutical composition based on the compound of formula [I] and to use of the compound with the formula [I].

EFFECT: obtaining novel triazolopyrine compounds, having inhibitory activity on prolyl hydroxylase and capable of inducing erythropoietin production.

30 cl, 34 tbl