DERIVATIVES OF PYRIDINE AND APPLICATION THEREOF AGAINST MICROBACTERIA Russian patent published in 2018 - IPC C07D213/64 C07D401/04 C07D401/06 C07D405/04 C07D409/04 C07D417/04 A61K31/4412 A61P31/06 A61P31/04 

FIELD: pharmaceutical.

SUBSTANCE: invention relates to a compound of formula (I) or pharmaceutically acceptable salt thereof, (I) where R₁ is selected from H, F, Cl, Br, I, R¹⁰¹ and where R¹⁰¹ is selected from following group consisting of phenyl, pyridyl, thienyl, furyl, thiazolyl, isothiazolyl, C_1-6 alkyl, N,N-di(C_1-6 alkyl)amino-(CH₂)_0-3, C_3-4 cycloalkyl, , where D₁₀₁ is selected from CH₂, O, S, NH and N(CH₃); D₁₀₂ represents CH₂ or a single bond; and T₁₀₁ is CH or N; and R¹⁰¹ is optionally substituted with 1, 2 or 3 F, Cl, Br, I, CN, CH₃, CF₃, CH₃O or CF₃O; m is 0, 1 or 2; R₂ is selected from H, halogen or the following group optionally substituted by 1, 2 or 3 R⁰¹: C_1-10 alkyl and C_1-10 alkoxy; R₃ is selected from the following group, optionally substituted with 1, 2 or 3 R⁰¹: 6-12-membered aryl, 6-12-membered arylalkylene and C_3-6 cycloalkyl; R₄ is C_1-8 alkyl optionally substituted with 1 R⁰¹; R₅ and R₆ each independently represents H or C_1-8 alkyl, where C_1-8 alkyl is optionally substituted 1 F, Cl, Br, I, CN, OH or CF₃; R₅ and R₆ together are optionally attached to one atom to form a 3 to 6-membered ring, optionally substituted with -OH; T₁ and T₂ each is independently selected from CH and N; X is selected from CH, -C(C_6-12 aryl)-, -C(halogen)- and -C(C_1-10 alkoxy)-; Y is selected from CH; R⁰¹ is selected from F, Cl, Br, I, CN, OH, CF₃, CF₃O, C_1-8 alkoxy and C_1-8 alkyl; "hetero" is a heteroatom or a group of heteroatoms selected from -NH-, -O-, -S- or N; where the number of heteroatoms or groups of heteroatoms is each independently selected from 0, 1, 2 or 3, which are used in the treatment of diseases, caused by mycobacteria, such as Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium and Mycobacterium marinum.

EFFECT: compound of formula or a pharmaceutically acceptable salt thereof.

11 cl, 110 ex, 3 tbl