PYRIMIDINE COMPOUND WITH CONDENSED RINGS, ITS INTERMEDIATE COMPOUND, METHOD OF PRODUCING, COMPOSITION AND USE Russian patent published in 2020 - IPC C07D495/04 C07D471/04 C07D239/84 A61K31/519 A61P35/00 A61P37/06 A61P25/28 A61P17/06 A61P19/02 A61P11/06 A61P9/04 A61P9/10 C07B59/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a pyrimidine compound with condensed rings of formula I or a pharmaceutically acceptable salt thereof, which have an inhibitory effect on Janus kinase, FGFR kinase, kinases FLT3 and/or kinase family Src. In formula IP is selected from hydrogen or deuterium; X is selected from CH or S; Y is selected from N or CR⁵; U is selected from a chemical bond or CH; V is selected from N or CH; W is selected from N or CR⁶; each of R¹, R², R³ and R⁶ is independently selected from group, consisting of hydrogen, deuterium, halogen, substituted or unsubstituted alkyl, , , ; each of R⁷, R⁸, R¹⁰ and R¹⁵ is independently selected from a group consisting of hydrogen, halogen, hydroxyl, substituted or unsubstituted alkyl, alkoxy, or 5-member heterocycloalkyl containing an oxygen atom in the ring; R¹¹ is alkyl; or R⁶, R² and two atoms in the ring, to which they are bonded, form unsubstituted 5-member carbon-containing heterocycle containing 1–2 oxygen atoms in the ring; R⁴ denotes a substituted or unsubstituted alkyl or substituted or unsubstituted 5–6 membered heterocycloalkyl containing a nitrogen atom or an oxygen atom as a heteroatom; R⁵ denotes hydrogen, halogen or alkyl. Invention also relates to methods of producing said compounds, intermediate compounds, a pharmaceutical composition containing compounds with condensed rings of formula I, and use thereof for producing medicinal agents which are used to prevent, relieve or treat diseases associated with Janus kinase, FGFR kinase, FLT3 kinase and/or Src family kinase.

EFFECT: disclosed are a pyrimidine compound with condensed rings, an intermediate compound thereof, a method of producing, a composition and use thereof.

21 cl, 4 tbl, 51 ex