METHOD OF TREATMENT OF CENTRAL CORNEAL ULCERS OF BACTERIAL AND HERPETIC ETIOLOGY Russian patent published in 2018 - IPC A61F9/01 A61K31/573 A61K39/245 A61P27/02 A61P31/04 

FIELD: medicine.

SUBSTANCE: invention relates to ophthalmology and is intended for the treatment of central corneal ulcers of bacterial and herpetic etiology. Carry out therapeutic treatment with etiotropic means, drugs that stimulate epithelization. Sensitization to antigens of the cornea is determined. If it is available, additionally, dexamethasone is injected parabulbarly every day, until the epithelialization of the ulcer and the resorption of the corneal infiltrate are completed. At a depth of ulceration up to 1/3 of the thickness of the stroma of the cornea, 1.2 mg of dexamethasone is injected in a volume of 0.3 ml. At a depth of ulceration up to 1/3–2/3 of the thickness of the stroma of the cornea, 0.8 mg of dexamethasone is injected in a volume of 0.2 ml. At a depth of ulceration up to 2/3 of the thickness of the stroma of the cornea, 0.4 mg of dexamethasone is injected in a volume of 0.1 ml.

EFFECT: method provides prevention of destruction of all layers of the cornea, reduction of edema and infiltration of the cornea, a reduction in uveitis in the first day after the start of treatment, early resorption of the infiltrate and epithelization of the corneal ulcer in a short time, prevention of corneal perforation, preservation and restoration of visual functions due to the use of a certain regimen of parabulbar injection of dexamethasone depending on the depth of stromal lesion in the corneal ulcer in the presence of autosensitization to corneal antigens.

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