FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology. Invention relates to a method for diagnosing myeloid malignancies. Method comprises determining the presence of a mutant allele of the calreticulin gene. If one or more mutant alleles of the calreticulin gene are present, the patient is suffering from a myeloid malignancy. Invention also includes genomic sequences, cDNA sequences, mRNA sequences and protein sequences of mutant calreticulin.
EFFECT: mutant calreticulin for the diagnosis of myeloid malignancies is disclosed.
62 cl, 10 dwg, 5 tbl, 2 ex
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