FIELD: medicine; pharmaceuticals.
SUBSTANCE: present invention relates to a film-coated tablet comprising a first film coating layer comprising hydroxypropyl methylcellulose and a second film coating layer comprising polyvinyl alcohol. Tablet contains granules consisting of choline alfoscerate as an active ingredient, magnesium aluminometasilicate as an additive, low-substituted hydroxypropylcellulose, microcrystalline cellulose and hydroxypropylcellulose, and a pharmaceutically acceptable excipient. Magnesium aluminometasilicate is present in the tablet in an amount of 0.35 to 0.45 part by weight per 1 part by weight of choline alfoscerate. Method for the preparation of a choline alfoscerate tablet with a double film coating is also described. Tablet of the invention is prepared by a conventional tablet manufacturing method, which is the least expensive. For the tablet obtained, the softening and hygroscopicity of choline alfoscerate is prevented.
EFFECT: choline alfoscerate tablet of the invention is manufactured with a size suitable for oral administration.
11 cl, 3 dwg, 8 tbl, 3 ex
