FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to variants of cytotoxic T-lymphocyte antigen 4 (CTLA-4), which can be used in medicine. CTLA-4 polypeptide with mutations is obtained, as well as, its IgG Fc conjugate, a host cell for producing a polypeptide, a composition comprising the polypeptide, which are used to treat an autoimmune disease and / or weaken the response of T cells in a patient.
EFFECT: invention allows, due to the high affinity and stability of the polypeptide, to increase the effectiveness of the treatment of an autoimmune disease and / or weakening the response of T-cells in a patient, for example, rheumatoid arthritis.
24 cl, 7 dwg, 12 tbl, 11 ex
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