FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, specifically to immunology, and can be used to prepare a bispecific fusion protein for a disease selected from an autoimmune disease and graft rejection. Bispecific fusion protein contains a ligand specific for CTLA-4 and a ligand specific for the pMHC complex, where the ligand specific for CTLA-4 and the ligand specific for the pMHC complex are separated by a linker.
EFFECT: use of this bispecific protein inhibits the immune response, impairing signal transmission by T cells in the early phase of T cell activation.
19 cl, 11 ex, 12 dwg
| Title |
Year |
Author |
Number |
| METHODS AND COMPOSITIONS FOR STABLE IMMUNOTHERAPY |
2014 |
|
RU2696876C2 |
| CARBOHYDRATE-MODIFIED PARTICLES AND POWDERED COMPOSITIONS FOR IMMUNE RESPONSE MODULATION |
2016 |
- Bryce, Paul, J.
- Chien, Karen, B.
|
RU2752620C2 |
| NUCLEIC ACIDS, CODING RECEPTOR CTLA-4 OF CAT, VECTORS, HOST CELLS, VACCINES, OLIGONUCLEOTIDES, POLYPEPTIDES CTLA-4 OF CAT AND METHODS FOR INDUCTION AND SUPPRESSION OF IMMUNE RESPONSE IN CAT |
1999 |
- Kollison Ehllen V.
- Choj In-Soo
- Uinslou Barbara Dzh.
- Kochran Mark D.
|
RU2377302C2 |
| ISOLATED NUCLEIC ACID ENCODING FELINE LIGAND CD86, DIAGNOSTIC OLIGONUCLEOTIDE, CLONING VECTOR, VACCINE, METHODS FOR INDUCTION OR SUPPRESSION OF IMMUNITY IN CAT |
1999 |
- Kollison Ehllen V.
- Choj In-Soo
- Uinslou Barbara Dzh.
- Kochran Mark D.
|
RU2263145C2 |
| SOLUBLE MEDIATOR |
2012 |
- Bandala Sanchez Ester
- Dromi Dzhejms
- Kharrison Leonard Charlz
- Chzhan Yujsya
- Rashidi Maryam
|
RU2660580C2 |
| NANOPARTICLE COMPOSITIONS FOR LONG-TERM THERAPY |
2016 |
|
RU2773380C2 |
| CHIMERIC ANTIGEN RECEPTORS WITH MUTATED CD28 COSTIMULATION DOMAINS |
2018 |
|
RU2800922C2 |
| METHOD OF HUMAN REGULATORY CD4CD25FOXP3T-CELL ENRICHMENT ex vivo |
2010 |
- Bykovskaja Svetlana Njunevna
- Karaulov Aleksandr Viktorovich
- Lysjuk Elena Jur'Evna
|
RU2437933C1 |
| COMPOSITIONS AND METHODS OF IMMUNOTHERAPY |
2014 |
- Fedorov Viktor D.
- Sadlejn Mishel
|
RU2729118C2 |
| BISPECIFIC ANTIBODIES TO CD25 AND Fc GAMMA-RECEPTOR FOR ELIMINATION OF TUMOR-SPECIFIC CELLS |
2017 |
- Kezada, Serkhio
- Peggs, Karl
- Arse Vargas, Frederik
|
RU2759970C2 |
