PREPARATION OF HYDROXY-BENZYLBENZENE DERIVATIVES Russian patent published in 2018 - IPC C07C37/00 C07C37/01 C07C39/367 C07F7/08

Abstract RU 2671493 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a process for the preparation of a compound of formula (I) wherein at least R⁴ is -OR^4a, R⁴ is selected from the group consisting of a hydrogen atom and a silyl group which are used as intermediates for the preparation of SGLT2 inhibitors. Method comprises preparing a reaction mixture comprising a compound of formula (II), a silane reducing agent selected from the group consisting of tetramethyldisiloxane (TMDS), pentamethyldisiloxane (PMDS), polymethylhydrosiloxane (PMHS), and Et₃SiH, a catalyst selected from the group consisting of B(C₆F₅)₃, -BF₃-THF, BF₃-Bu₂O, BF₃-MeCN, BF₃AcOH, BF₃H₃PO₄ and BF₃, and a solvent. (I) (II).

EFFECT: process according to the invention makes it possible to obtain the desired products in high yield.

23 cl, 9 dwg, 9 ex

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RU 2 671 493 C2

Authors

Roberzh Zhak

Vakseler Karin

Lyu Baokhu

Syuj Ge

Chzhan Tszyan

Tan Sinsin

Syuj Bajkhua

Dates

2018-11-01—Published

2014-10-11—Filed