HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USE THEREOF Russian patent published in 2021 - IPC C07D233/88 C07D401/04 C07D403/04 C07D405/04 C07D413/04 C07D471/08 A61K31/4184 A61K31/4439 A61K31/506 A61P1/00 A61P3/00 A61P17/00 A61P19/00 A61P25/00 A61K35/00 

FIELD: chemical engineering.

SUBSTANCE: present invention relates to compound of formula I

I

or pharmaceutically acceptable salt thereof. In formula I: represents 3- to 7-membered heterocyclic ring, having 1 to 3 heteroatoms independently selected from nitrogen or oxygen; each R^a independently represents C₁-C₃ alkyl, -(CH₂)-cycloalkyl or -C(O)C₁-C₃ alkyl; R^b represents -ОН or C₁-C₃ alkyl; or R^b is absent; ring X represents phenil; R¹ represents haloalkyl; R² represents hydrogen; R³ represents C₁-C₆ alkyl or C₂-C₆ alkenyl, each unnecessarily and independently repaced by groups 1-3 selected independently from –OH and halogen; R⁴ represents hydrogen; and p equals to 0, 1, 2 or 3. Disclosed are also a pharmaceutic composition, a method for inhibition of IRAK or its mutant in patient or in biological sample and a method for treating IRAK-caused disorder.

EFFECT: suggested compounds have inhibitory activity in relation to IRAK and may be useful when treating IRAK-caused disorder.

14 cl, 2 tbl, 64 ex