SUBSTITUTED HETEROCYCLIC SULPHONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS Russian patent published in 2018 - IPC C07D403/12 C07D403/14 C07D401/12 C07D401/14 C07D417/14 C07D451/02 A61K31/4025 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula II where A is , B is B², and R⁵ represents R^5b; B² is pyridinyl, wherein any pyridinyl B² is optionally substituted with one or more groups independently selected from a halogen atom, (C₁-C₆)alkyl, -O(C₁-C₆)alkyl, -O(C₁-C₆)alkyl-O(C₁-C₆)alkyl, (C₃-C₇)cycloalkyl, (C₁-C₆)haloalkyl, -CN and 6-membered heteroaryl, wherein any 6-membered heteroaryl is optionally substituted with one or more than one (C₁-C₆)alkyl or (C₁-C₆)haloalkyl; R¹ is phenyl, 5-membered heteroaryl or 6-membered heteroaryl, wherein any phenyl, 5-membered heteroaryl or 6-membered heteroaryl R¹ is optionally substituted with one or more groups independently selected from a halogen atom, -CN, (C₁-C₆)alkyl and (C₁-C₆)haloalkyl; one of the R^3b groups represents a halogen atom, -CN or (C₁-C₆)alkyl, and the other R^3b groups are independently selected from H, (C₁-C₆)alkyl and (C₁-C₆)haloalkyl; R⁴ represents H, (C₁-C₆)alkyl or (C₁-C₆)haloalkyl; R^5b represents and salts thereof.

EFFECT: compounds may be useful in the treatment of diseases and conditions mediated by A1 channels with transient receptor potential (TRPA1).

39 cl, 5 tbl, 201 ex