AMINOPYRIMIDINE KINASE INHIBITORS Russian patent published in 2018 - IPC C07D417/06 C07D417/14 C07F9/6558 A61K31/506 A61K31/5377 A61K31/675 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula 1, or a pharmaceutically acceptable salt thereof, where the values of X are -N(R₇)₂, -N(R₇)(R₂) or -N(H)-R₃-R₆; R' represents H or methyl; R₂ represents H, -CH₂OP(=O)(OH)₂ or -(C=O)OCHR₈O(C=O)CH₃; R₃ represents -C(=NR)- or -(C(R)₂)_n-; R₅ is selected from the group consisting of 1,4-cyclohexanediyl and 1,4-phenylene; R₆ is selected from the group consisting of aryl selected from the group consisting of phenyl and naphthalenyl, and heteroaryl selected from the group consisting of pyrimidine, pyridine, quinoline, benzofuran, pyrazine and furan, any of which is optionally mono- or disubstituted and the substituents, if present, are independently selected from the group consisting of alkyl, phenyl, heteroaryl, selected from the group consisting of thiophene, furan, pyridine, benzofuran, pyrazole and pyrrole, alkoxy, hydroxy, perfluoroalkyl, trifluoromethoxy, dialkylamino, perfluoroethoxy and halide, wherein the optional phenyl or heteroaryl substituent may contain alkyl, halide, alkoxy, perfluoroalkyl or dioxolanyl as substituents; R₇ is selected from the group consisting of H and -CH₂-pyridine, any of which is optionally monosubstituted, and the substituent, if present, is thiophene; or two R₇ and the nitrogen to which they are bonded, together represent morpholine; R₈ is H; R is H or (C₁-C₄)alkyl; and n is 1, 2 or 3. Invention also relates to compounds of the formula 2, 3, 5 and 6 or a pharmaceutically acceptable salt thereof, where X, R', R₁, R₂, R₃, R₆ and n are given in the claims.

(1), (2), (3), (5), (6).

EFFECT: compounds of the invention are intended for the treatment of cancer.

29 cl, 4 tbl, 118 ex