RECTAL SUPPOSITORIES AND METHOD FOR PREPARATION THEREOF (OPTIONS) Russian patent published in 2018 - IPC A61K9/02 A61K31/341 A61K31/355 A61K38/21 A61K47/02 A61K47/12 A61P31/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to the technology of creating a drug in the form of rectal suppositories based on interferon for the treatment of infectious and inflammatory diseases. Preparation of rectal suppositories is carried out in two stages, pre-mixed 0.01–1 mg/g of sulfite or sodium metabisulfite, 10–60 mg/g of ascorbic acid, 5–30 mg/g of sodium bicarbonate or carbonate, 0.05–0.2 mg/g of Trilon B, 0.05–0.2 mg/g of polysorbate 80 and water purified from oxygen, the resulting mixture is injected 50,000–5,000,000 IU/g of interferon alpha-2b and sterilized by filtration, then 30–100 mg/g α-tocopherol, 700–800 mg/g of a mixture of Witepsol H15 and Witepsol W35 is melted at a temperature of 35–45 °C and vigorously stirred, raising the temperature to 70–120 °C, then cooled to 32–35 °C and combine with vigorous stirring with the mixture of the first stage, preheated to 32–35 °C, then the suppositories are molded.

EFFECT: technical result is the stabilization of the quality of suppositories, increasing the shelf life and preventing the oxidation of ingredients during the preparation and storage of finished forms.

2 cl, 6 ex