ANTIVIRAL AGENT IN LIQUID FORM AND METHOD FOR ITS PREPARATION Russian patent published in 2022 - IPC A61K9/08 A61K38/21 A61K47/02 A61K47/10 A61K47/18 A61K47/58 A61P31/12 

FIELD: interferon-containing compositions production.

SUBSTANCE: inventions group relates to a technology for preparing interferon-containing compositions capable of maintaining their biological activity, which can be used as drugs for intranasal use, for example, in the form of drops or spray. The proposed method for preparing an antiviral agent in liquid form is characterized in that the following composition is used for preparation, mg in one ml: genetically engineered interferon, ME 1000-500000, povidone 5-100, macrogol 10-600, disodium edetate dihydrate 0.1- 0.8, sodium hydrophosphate dodecahydrate 5-20, potassium dihydrophosphate 1-10, sodium chloride 1-10, water - the rest, at the same time, the preparation is carried out in two stages, at the first of which sodium hydrogen phosphate dodecahydrate, potassium dihydrogen phosphate, sodium chloride, disodium edetate dihydrate, povidone and macrogol are successively dissolved in water at room temperature, and the kinematic viscosity of the solution is maintained in the range of 2.5-4, 5 mm²/s, adjusting the amount and ratio of povidone and macrogol, after which the solution is filtered and sterilized, and at the second stage, the genetically engineered interferon is heated to a temperature of 19-21°C, then, under aseptic conditions, it is gradually introduced into the solution of the first stage with a laminar flow and mixed. An antiviral agent is also provided in liquid form, obtained by the above method.

EFFECT: increasing the shelf life without reducing the activity of interferon, which is achieved by the technology of preparing an antiviral agent.

2 cl, 9 ex