METHOD FOR PREDICTING THE PROBABILITY OF DEVELOPING ADENOMYOSIS IN WOMEN WITH UTERINE MYOMA Russian patent published in 2018 - IPC A61B5/00 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, namely to gynecology, and can be used to predict the likelihood of developing adenomyosis in women with uterine myoma. Age is checked. Anamnestic data is collected. Additionally, the following markers are determined: the level of lactoferrin in the blood (LF), the level of interleukin 6 (IL-6) in the blood, the base score. Prognostic factor (PF) is set as the sum of points for each factor. Points of each factor are set. In the system “age”, marker “age under 42 years old” receives 0 points, marker “age 43 years and older” receives +8 points. In the system “concomitant endometrial hyperplasia”, marker "available endometrial hyperplasia" receives +15 points, marker "no endometrial hyperplasia" – 0 points. In the system “chronic inflammation of the cervix”, marker "available chronic inflammatory processes of the cervix" receives +7 points, marker "no chronic inflammatory processes of the cervix" receives 0 points. In the system “hyperpolymenorrhea”, marker "available hyperpolymenorrhea" receives +16 points, marker "no hyperpolymenorrhea" receives 0 points. In the system “presence of childbirth”, marker “available childbirth” receives +22 points, marker “no childbirth” receives 0 points. In the system “pathology of the endometrium in history”, marker "available endometrial pathology” receives +25 points, marker “no endometrial pathology” receives 0 points. In the system “varicose disease of the lower extremities” marker "available varicose disease of the lower extremities" receives +21 points, marker "no varicose disease of the lower extremities" receives 0 points. In the system “apendenctomy in the history”, marker “available apendectomy in history” receives +14 points, marker “no adenectomy in history” receives 0 points. In the system “level of lactoferrin in the blood” marker "level of lactoferrin in the blood is more than 1.18 mg/l" receives +14 points, marker “level of lactoferrin in the blood is 1.18 mg/l or less” receives 0 points. In the system “level of IL-6 in the blood” marker "level of IL-6 in the blood is more than 2.8 pg/ml" receives +10 points, marker "level of IL-6 in the blood is 2.8 pg/ml or less" receives 0 points. Base score is set to +10. When the value of the sum of PF has a base score of 100 points and above, a high probability of developing fibroids in combination with adenomyosis is predicted. When the value of the sum of PF has a base score of less than 100 points, a low probability of developing fibroids in combination with adenomyosis is predicted.

EFFECT: method provides an effective prediction of the risk of adenomyosis in combination with myoma and the choice of an effective management tactic for patients due to the use of significant risk factors in the prediction.

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