METHOD FOR OBTAINING DICYCLOPLATIN Russian patent published in 2018 - IPC C07F15/00 A61K31/282

Abstract RU 2676269 C1

FIELD: technological processes.

SUBSTANCE: invention relates to a method for producing dicycloplatin of formula (I) . This method involves combining carboplatin with an appropriate proportion of 1,1-cyclobutane dicarboxylic acid and solvent to form a suspension, separating the precipitated solid phase from the suspension and drying the solid phase, where the solid phase contains dicycloplatin of formula (I) without the presence of a detectable amount of carboplatin. Further, the molar ratio of carboplatin and 1,1-cyclobutane dicarboxylic acid in the combining step is from about 1:1.15 to about 1:50.

EFFECT: method according to the invention is easy to use, includes mild conditions, fast reaction time, high reproducibility and allows to obtain a product that does not contain carboplatin in detectable amounts.

14 cl, 7 dwg, 10 tbl, 11 ex

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RU 2 676 269 C1

Authors

Lyu Syaochzhun

Si Tszizhuj

Chzhao E

Chzhan Lyan

Dates

2018-12-27—Published

2015-04-10—Filed