CARBOPLATIN COMPLEX AND PHARMACEUTICAL PREPARATION BASED THEREON Russian patent published in 2024 - IPC C07F15/00 A61K31/282 A61K47/54 A61P31/04 A61P31/10 A61P31/12 A61P35/00 G01N23/20 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a carboplatin complex, which is a complex formed by combining carboplatin and 1,1-cyclobutanedicarboxylic acid through two hydrogen bonds, wherein each of the two hydrogen bonds is formed between the carbonyl oxygen of the carboplatin molecule and the carboxyl hydrogen of 1,1-cyclobutanedicarboxylic acid molecule, where the structure of said carboplatinum complex is given below. Proposed method involves mixing carboplatin and 1,1-cyclobutanedicarboxylic acid in molar ratio of 1:1.5–3 at 65 °C ± 10 °C for at least 0.5 h to obtain a supersaturated aqueous solution and collecting crystals of the carboplatin complex. Also disclosed is a method of producing a pharmaceutical preparation and a method of controlling quality of a carboplatin complex.

EFFECT: invention enables to obtain a stable complex formed by carboplatin and 1,1-cyclobutanedicarboxylic acid due to non-covalent bonds, which has very high purity as an end product.

7 cl, 14 dwg, 1 tbl, 3 ex