TARTRATE 3-((1R,3R)-1-(2,6-DIFLUORINE-4-((1-(3- FLUOROPROPYL)AZETIDINE-3-YL)AMINO)PHENYL)-3-METHYL-1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-b]INDOLE-2-YL)-2,2-DIFLUOROPROPANE-1-OL, ITS SOLID FORMS, METHOD OF ITS PREPARATION AND THEIR APPLICATION Russian patent published in 2023 - IPC C07D471/04 A61K31/437 A61P35/00 

Abstract RU 2809220 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a process for the preparation of compound B

and includes the following stages:

EFFECT: obtaining methods of the production of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl tartrate -1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, which can be used in the treatment of cancer.

5 cl, 38 tbl, 34 ex, 39 dwg

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RU 2 809 220 C2

Authors

Chunk, Chol Keun

Syuj, Tsze

Iding, Khans

Klagg, Kajl

Delzil, Majkl

Fettes, Alek

Gosselin, Frensis

Lim, Ngiap-Kie

Makklori, Endryu

Chzhan, Khajmin

Chakravarti, Paroma

Nagapudi, Kartik

Robinson, Sara

Dates

2023-12-07Published

2019-06-17Filed