LUTETIUM-177 TRICHLORIDE PRODUCTION METHOD AND PROCESS LINE FOR ITS IMPLEMENTATION Russian patent published in 2019 - IPC G21G1/00 G21G4/08 A61K51/00 

FIELD: medicine; nuclear physics.

SUBSTANCE: invention relates to production process of radionuclides for nuclear medicine. Lutetium trichloride-177 production method includes the target manufacturing by the lutetium-176 oxide starting material dissolving in nitric acid at a temperature of 90 °C, obtained material dispensing into the quartz ampoule, the material evaporation from the ampoule until dry at 110 °C, the quartz ampoule sealing in vacuum and placing the ampoule into the target made in the form of an aluminum capsule, the target irradiation in the reactor for 10 effective days, after irradiation, the aluminum capsule is deactivated with nitric acid at concentration of 6 mol/l for 10 minutes, washed with distilled water, opened, the quartz ampule is removed, and deactivated with nitric acid at concentration of 4 mol/l for 40 minutes at a temperature of 70 °C, washed with distilled water and dried, measuring the quartz ampoule surface contamination level by the smear method, then placing the deactivated quartz ampoule into the protective box, where repeated decontamination is performed and the quartz ampoule surface contamination level is measured again, if the contamination level does not exceed 185 Bq, the quartz ampule is cut around the circumference with an abrasive tool, washed and opened, then the lutetium-177 dry precipitate in a quartz ampoule is dissolved in hydrochloric acid with a concentration of 0.1 mol/l, then removed and metered into vials, packaged into containers for transportation to the consumer. Lutetium trichloride-177 production technological line is also proposed, including a laminar box, a welding station, a reactor complex, a hot chamber, radiation protection boxes, a laboratory for the finished product quality control, and a fume hood.

EFFECT: invention provides the simplified lutetium-177 trichloride precursor preparation process without a carrier at standard reactors.

2 cl, 1 dwg, 1 tbl