METHODS FOR SYNTHESIS OF RADIONUCLIDE COMPLEX Russian patent published in 2024 - IPC A61K51/08 C07B59/00 A61K103/30 

FIELD: chemistry.

SUBSTANCE: present invention relates to a method for synthesis of a radionuclide complex formed by a radionuclide and a peptide which binds a somatostatin receptor coupled with a chelating agent. Proposed method includes the following steps in the following order: a) introduction of the radionuclide precursor solution into the first vessel, b) transfer of the radionuclide precursor solution into the reactor, c) adding a working buffer solution into said first vessel containing a residual solution of the radionuclide precursor, d) transfer of working buffer solution and residual solution of radionuclide precursor from said first vessel into reactor, e) transferring a solution containing a peptide binding a somatostatin receptor coupled to a chelating agent into a reactor, f) reacting a peptide binding a somatostatin receptor coupled to a chelating agent with said radionuclide in a reactor to obtain a radionuclide complex, g) extraction of said radionuclide complex, where pH at step f) is between 3.0 and 7.0, and temperature at reaction step f) is in range of 80–100 °C.

EFFECT: invention provides high labelling output correlating with high radiochemical purity, high labelling output with minimum level of free (non-complexed) radionuclide, production of large number of doses in single batches.

24 cl, 6 dwg, 8 tbl, 2 ex