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2 679 130

(13)

(51)

IPC

C07D471/04(2006-01-01)

C07D239/84(2006-01-01)

A61K31/4375(2006-01-01)

A61K31/517(2006-01-01)

A61K31/519(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2015104342, 2013-07-11

(24)

Start date

2013-07-11

(22)

Actual filing date

2013-07-11

(45)

Published

2019-02-06

(72)

Inventor

Bifalko Nil Ml.Brojmans NatashaKhodaus Brajan L.Kim Dzhozef L.Miduturu Chandrasekkhar V.Venglovski Stiven Mark

(73)

Holder

Blyuprint Medsins Korporejshn

INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR Russian patent published in 2019 - IPC C07D471/04 C07D239/84 A61K31/4375 A61K31/517 A61K31/519 A61P35/00

Abstract RU 2679130 C2

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, specifically to a heterocyclic compound of formula I, where ring A is phenyl; X is CH or N; Y is CH, N or NR⁴, where R⁴ is methyl; L is a bond; each of R¹-R³ independently represents halogen, methyl, methoxy, CF₃ or unsubstituted morpholine; m is 0–2; n is 4; p is 0–2; and the head part is , where each of R^a, R^b and R^c independently represents H or methyl. Invention also relates to specific compounds, a pharmaceutical composition based on a compound of formula I or a specific compound, their use and a method for treating said diseases. .

EFFECT: technical result: obtaining new heterocyclic compounds with inhibitory activity against the fibroblast growth factor receptor 4 (FGFR-4).

20 cl, 9 dwg, 17 ex

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RU 2 679 130 C2

Authors

Bifalko Nil Ml.

Brojmans Natasha

Khodaus Brajan L.

Kim Dzhozef L.

Miduturu Chandrasekkhar V.

Venglovski Stiven Mark

Dates

2019-02-06—Published

2013-07-11—Filed