COMPOSITIONS SUITABLE FOR TREATING DISORDERS ASSOCIATED WITH KIT Russian patent published in 2019 - IPC C07D487/04 A61K31/53 A61P35/00 

FIELD: chemistry; pharmaceutics.

SUBSTANCE: invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof. In formula IW is selected from hydrogen and , where Ring A is selected from phenyl or 6-member monocyclic heteroaryl with one ring heteroatom selected from N; each X and Y is independently selected from CR¹ and N; Z is selected from phenyl, 5- or 6-membered monocyclic heteroaryl with 1–2 ring heteroatoms independently selected from N, O and S, 6-membered monocyclic partially unsaturated heterocyclyl with one ring heteroatom selected from N; where each of phenyl, monocyclic heteroaryl and monocyclic heterocyclyl is independently substituted with 0–2 groups R^C; L is selected from bond, -(C(R²)(R²))_m-, -(C₂-C₆ alkynylene)-, -O-, -S- and -S(O)₂-; each R^A and R^B is independently selected from halogen, C₁-C₆ alkyl and C₁-C₆ hydroxyalkyl; each R^C is independently selected from C₁-C₆ alkyl, C₁-C₆ alkoxy, halogen, C₁-C₆ hydroxyalkyl, C₃-C₇ cycloalkyl, 4-member heterocyclyl with one ring heteroatom selected from O, (6-member heterocyclyl with 2 ring heteroatoms selected from N, O)-C₁-C₆ alkyl, cyano, -C(O)OR² and -C(O)-N(R²)(R²); each R^D and R^F is independently selected from hydrogen and -N (R²) (R²); each R¹ is hydrogen; each R² is independently selected from hydrogen, hydroxyl, -NR "R", C₁-C₆ alkyl, C₁-C₆ alkoxy, C₁-C₆ haloalkyl, C₁-C₆ hydroxyalkyl, C₃-C₇ cycloalkyl, or 2 R² together with atoms, to which they are bonded, form 4-member heterocyclyl ring with 1 ring atom selected from O; each R "is hydrogen or C₁-C₆ alkyl; and m, p and q – each independently represent 0, 1, 2, 3 or 4. Invention also relates to individual compounds, to a pharmaceutical composition, to methods of treatment.

I.

EFFECT: technical result is obtaining novel compounds of formula I, having modulating activity on KIT and/or PDGFRα.

25 cl, 2 dwg, 3 tbl, 7 ex