FIELD: medicine.
SUBSTANCE: invention relates to medicine, namely to pharmacology. Use of sodium salt of 11H-indeno[1,2-b]quinoxalin-11-one-oxime as a neuroprotective agent with antioxidant properties and the donator of nitric oxide has been proposed. Technical effect: the use of sodium salt of 11H-indeno[1,2-b]quinoxaline-11-one-oxime among mice with ischemia/reperfusion of the brain reduces the size of the focus of necrosis and the degree of neurological deficit, increases blood levels of nitric oxide; by antioxidant activity, the compound is not inferior to the reference ionol preparation.
EFFECT: invention can be used to treat cerebrovascular diseases.
1 cl, 4 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIHYPERTENSIVE AGENT | 2020 |
|
RU2740379C1 |
| CEREBROVASCULAR AGENT | 2019 |
|
RU2791639C2 |
| NEUROPROTECTOR | 2009 |
|
RU2406488C1 |
| AGENT POSSESSING ANTIAGGREGANT ACTIVITY | 2019 |
|
RU2696583C1 |
| USE OF PHARMACEUTICAL COMPOSITION CONTAINING CHOLINE ALFOSCERATE AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE AS NEUROPROTECTIVE AGENT IN CEREBRAL ISCHEMIA | 2023 |
|
RU2819828C1 |
| AGENT POSSESSING NEUROPROTECTIVE ACTIVITY | 2018 |
|
RU2701739C1 |
| AGENT POSSESSING ANTIRADICAL, CEREBROPROTECTIVE AND ANTIISCHEMIC PROPERTIES | 2010 |
|
RU2445090C1 |
| AGENT WITH NEUROPROTECTIVE ACTIVITY | 2019 |
|
RU2800955C2 |
| BICYCLIC PYRIMIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS - ANTIOXIDANT PROGRAMME ACTIVATORS AND USING THEM AS CYTOPROTECTORS | 2014 |
|
RU2545758C1 |
| MEDICINAL COMPOSITION | 2001 |
|
RU2213562C2 |
