FIELD: medicine.
SUBSTANCE: present invention relates to immunology. Proposed is a humanized antibody or a functional fragment thereof that specifically binds to beta-1 integrin. In addition, a nucleic acid molecule encoding an antibody or a fragment thereof, as well as an expression vector and a host cell, is provided. Disclosed is a pharmaceutical composition, immunoconjugates containing an antibody associated with a detectable or therapeutic group, a treatment method and a method for detecting a disease associated with expression of integrin beta-1.
EFFECT: invention may find further application in the treatment and diagnosis of various types of cancer and inflammatory diseases.
34 cl, 32 dwg, 3 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ALPHA5-BETA 1 ANTIBODIES AND USING THEM | 2009 |
|
RU2528736C2 |
| PEPTIDE OR PEPTIDE COMPLEX BINDING TO alpha2- INTEGRIN, METHODS FOR PRODUCTION AND USE THEREOF | 2011 |
|
RU2588668C2 |
| NOVEL ANTIBODIES | 2008 |
|
RU2490277C2 |
| CHIMERIC AND HUMANISED INTEGRIN α5β1 ANTIBODIES MODULATING ANGIOGENESIS | 2003 |
|
RU2346701C2 |
| ANTI-INTEGRIN ALPHA-2 ANTIBODIES AND USING THEM | 2011 |
|
RU2545401C2 |
| ANTI-αvβ8 ANTIBODIES AND COMPOSITIONS AND THEIR USE | 2019 |
|
RU2812478C2 |
| ANTIBODIES AGAINST PD-1 AND THEIR USE | 2018 |
|
RU2788616C2 |
| COMPOSITIONS AND METHODS FOR SUPPRESSION OF CANCER STEM CELLS | 2016 |
|
RU2752610C1 |
| METHOD OF DESTROYING CELLS USING EFFECTOR FUNCTIONS OF ANTI-EphA4 ANTIBODIES | 2007 |
|
RU2429246C2 |
| ANTI-TUMOUR ANTIGEN ANTIBODY AND METHODS OF APPLICATION | 2011 |
|
RU2598711C2 |
