FIELD: chemistry.
SUBSTANCE: described are recovered monoclonal antibody or its antigen-binding fragment, wherein above antibody or fragment specifically bound with I-domain α of human α2-integrin, nucleic acid coding this antibody and cell containing this nucleic acid. Method of producing said antibody, pharmaceutical composition and kits containing this antibody. Invention also discloses methods for diagnosing and treating, using this antibody.
EFFECT: invention provides specific inhibitor of α2-integrin.
47 cl, 14 dwg, 14 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBODIES AND POLYPEPTIDES AGAINST CD127 | 2017 |
|
RU2769352C2 |
| ANTIBODY TO PD-L1, ITS ANTIGEN-BINDING FRAGMENT, AND THEIR PHARMACEUTICAL USE | 2019 |
|
RU2778085C2 |
| MONOCLONAL ANTIBODIES AGAINST HUMAN TIM-3 | 2019 |
|
RU2777336C1 |
| PROTEIN BOUND WITH HUMAN GLYCOPROTEIN, COMPOSITION, PHARMACEUTICAL COMPOSITION, EXPRESSION VECTOR | 2016 |
|
RU2773819C2 |
| BISPECIFIC PROTEIN | 2019 |
|
RU2784486C1 |
| ANTIBODIES TO HUMAN INTERLEUKIN-2 AND THEIR APPLICATION | 2018 |
|
RU2745451C1 |
| ANTIBODIES BINDING TO HLA-A2/WT1 | 2018 |
|
RU2815176C2 |
| ANTIBODY AGAINST B7-H3, ITS ANTIGEN-BINDING FRAGMENT AND THEIR MEDICAL USE | 2018 |
|
RU2765306C2 |
| MONOCLONAL ANTIBODY WHICH SPECIFICALLY BINDS GITR | 2019 |
|
RU2734432C1 |
| HER-2-DIRECTED ANTIGEN-BINDING MOLECULES CONTAINING 4-1BBL | 2019 |
|
RU2815451C2 |
