BICYCLIC CONDENSED HETEROARYL OR ARYL COMPOUNDS AS IRAK4 MODULATORS Russian patent published in 2019 - IPC C07D207/273 C07D401/12 C07D401/14 C07D413/14 C07D471/04 C07D491/18 A61K31/4015 A61K31/4025 A61K31/4375 A61K31/4709 A61K31/4725 A61K31/4748 A61P11/00 A61P25/00 A61P29/00 A61P35/00 

Abstract RU 2684324 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a heterocyclic compound of formulas IIc or IIe, where R1 represents C1-C6alkyl; R2 is hydrogen; R3 is hydrogen; each of R4a and R4b independently represents hydrogen or fluorine; R5a and R5b independently represent hydrogen or C1-C3alkyl; and R6 is hydrogen. Invention also relates to specific compounds and pharmaceutical compositions based on these compounds. (IIc IIe).

EFFECT: technical result: new heterocyclic compounds with IRAK4-inhibiting activity have been obtained.

3 cl, 33 ex, 1 tbl

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RU 2 684 324 C1

Authors

Lee Katherine Lin

Allais Christophe Philippe

Dehnhardt Christoph Martin

Gavrin Lori Krim

Han Seungil

Hepworth David

Lee Arthur

Lovering Frank Eldridge

Mathias John Paul

Owen Dafydd Rhys

Papaioannou Nikolaos

Saiah Eddine

Strohbach Joseph Walter

Trzupek John David

Wright Stephen Wayne

Zapf Christoph Wolfgang

Dates

2019-04-08Published

2016-08-16Filed