METHODOLOGY PREPARATIONS Russian patent published in 2019 - IPC A61K9/20 A61K31/421 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to a metachsalon dosage form. Dosage dosage form comprises 300 or 600 mg of metaxalone for relieving discomfort associated with acute painful musculoskeological conditions, wherein the dispensed dosage form contains a surfactant and at least one of mannitol, sorbitol, isomalt, xylitol, maltitol, lactitol, erythritol, arabitol, ribitol, glucose, fructose, mannose, galactose, anhydrous lactose, lactose monohydrate, sucrose, maltose, trehalose, maltodextrins, dextrin and inuline, the average size of metaxalone particles is between 50 and 900 nm, wherein rate of dissolving metaksalone, determined using tester using 1000 ml of 0.01 n. HCl at pH = 2 at 37 °C and a vane device for dissolving type 2 at a rotation speed of 100 rpm, such that at least 80 % is dissolved for 60 minutes.

EFFECT: relief of acute painful musculoskeological pathological conditions.

46 cl, 3 ex, 3 dwg, 8 tbl