NEEDLE-FREE INJECTOR AND METHOD OF INTRODUCING DNA INTO THE TARGET AREA OF INJECTION WITH USING IT Russian patent published in 2019 - IPC A61M5/303 A61D7/00 A61K31/7088 

FIELD: medicine.

SUBSTANCE: invention refers to medical equipment, namely to a method for introducing DNA containing an area coding a tumor antigen into a living mammal by applying a needle-free injector. Needle-free injector is configured to inject the DNA solution into the target injection region without using the injection needle. Injector includes an accommodation unit configured to receive a DNA solution therein. Injector has an ignition device comprising a powder igniter configured to provide a pressure characteristic, providing generation of plasma during combustion immediately after ignition with subsequent provision of reduction of created pressure when temperature becomes room temperature. Ignition device includes combustion product liquefied due to absence of content of gas component in combustion product or due to content of certain gas component in combustion product, amount of which is reduced relative to quantity presented before liquefaction. Injector includes neck assembly having outlet hole made with possibility of passage through it of DNA solution compressed by combustion of powder igniter in ignition device, so that DNA solution is released into target area of injection. Injector comprises piston and plunger. Temperature of the combustion product provided during compression changes to temperature close to room temperature within 20 ms, after pressure applied to the DNA solution as a result of burning of the powder igniter reaches the initial peak output force during the compression process for solution discharge DNA.

EFFECT: method enables to produce antibodies, the production of which is favorable, and do not produce an antibody, the production of which is not favorable, that is, a needle-free injector which can selectively induce an immune response, and a method for introducing DNA containing an antigen-encoding portion for selective antibody production in a living mammal by using a needle-free injector.

5 cl, 6 dwg