FUSED PROTEINS WITH IMMUNOGLOBULIN FC-FRAGMENT FOR ENHANCING IMMUNOGENICITY OF PROTEIN AND PEPTIDE ANTIGENS Russian patent published in 2005 - IPC

FIELD: medicine, immunology, pharmacology.

SUBSTANCE: immunogenicity is enhanced by fusion of preliminary taken antigen with the immunoglobulin heavy chain constant region for preparing the fused protein Fc-antigen. Fused proteins Fc-antigen are bound by receptors for Fc on surface antigen-representing cells and providing the target direction of antigen to antigen-representing cells. Also, invention discloses family of adjuvants. For example, invention describes the fused protein Fc-adjuvant for using in combination with fused proteins Fc-antigen to enhance or to modulate the specific immune response to preliminary taken antigen. Invention provides expanding assortment of agents used for stimulation of immunity.

EFFECT: valuable biological and medicinal properties of fused proteins.

27 cl, 14 dwg, 1 tbl, 11 ex