FIELD: medicine; biotechnology.
SUBSTANCE: invention refers to biotechnology and molecular biology. Disclosed is a lentiviral vector for treating cancer, containing left (5') lentiviral LTR containing a heterologous promoter of cytomegalovirus (CMV), Psi (Ψ) a packing signal, a central polypurine path/DNA-flap (cPPT / FLAP), a rev response element (RRE); (3') lentiviral self-inactivating (SIN) LTR; a synthetic polyadenylation sequence and a polynucleotide comprising a promoter (MND) with a myeloproliferative sarcoma virus enhancer, with a negative-control portion removed, with a primer binding site substituted with a dl587rev sequence operatively linked to a nucleic acid coding a chimeric antigenic receptor (CAR).
EFFECT: invention can be used for treating cancer in medicine.
12 cl, 9 dwg, 4 tbl, 8 ex
| Title |
Year |
Author |
Number |
| CHIMERIC ANTIGENIC RECEPTORS WITH MND PROMOTER |
2015 |
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- Ryu, Byoung
|
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2015 |
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2015 |
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2015 |
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|
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2018 |
|
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2016 |
|
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| OPTIONS, COMPOSITIONS, AND METHODS FOR USE OF ENDONUCLEASE CBLB |
2018 |
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|
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| MODIFIED MONOCYTES/MACROPHAGES EXPRESSING CHIMERIC ANTIGEN RECEPTORS AND THEIR APPLICATIONS |
2016 |
- Gill, Saar
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- June, Carl H.
|
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| METHODS OF EXPANSION OF ANTIGEN-SPECIFIC CAR-T-CELLS, COMPOSITIONS AND THEIR USE |
2019 |
- Aftab, Blake, T.
- Pham, Christina
- Shen, Rhine
- Wu, Michelle
|
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| CHIMERIC ANTIGEN RECEPTOR WITH COSTIMULATORY DOMAIN 4-1BB |
2020 |
- Kwon, Byoung S.
- Kim, Kwanghee
- Chung, Jiwon
- Chang, Young Gyoon
- Yi, Bo-Rim
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|
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