FIELD: biotechnology.
SUBSTANCE: disclosed is a kit containing a bispecific antibody molecule and material required for genetic transduction of CD8+T-cells, wherein the bispecific antibody molecule comprises a CD8+T-cell-transducing antigen binding domain, and a tumour-specific antigen binding domain. Also disclosed is use of a pharmaceutical composition containing said bispecific antibody molecule, in combination with genetically transduced CD8+T-cells for treating oncological disease and methods of treating oncological disease.
EFFECT: present invention provides targeted mobilization of CD8+T-cells into a tumour using bispecific antibody molecules that can be used in adoptive therapy.
29 cl, 24 dwg, 1 tbl, 5 ex
| Title |
Year |
Author |
Number |
| IMPROVED ANTIGEN-BINDING RECEPTORS |
2018 |
- Stubenrauch Kay-Gunnar
- Moessner Ekkehard
- Klein Christian
- Darowski Diana
|
RU2825816C2 |
| COMBINATION CONTAINING MULTIFUNCTIONAL ANTIBODIES REDIRECTING T-CELLS AND CONTROL POINT MODULATORS, AND ITS APPLICATIONS |
2017 |
|
RU2773655C2 |
| MULTI-SPECIFIC ANTIBODIES INTENDED FOR USE IN TREATMENT OF URINARY TRACT NEOPLASM |
2017 |
- Lindkhofer Khorst
- Bauer Khartvig-Vilgelm
|
RU2766358C2 |
| BISPECIFIC BINDING AGENTS FOR MODULATING BIOLOGICAL ACTIVITY |
2005 |
- Nilsen Ulrik B.
- Shoehberl' Birgit M.
|
RU2433831C2 |
| USE OF BISPECIFIC ANTIGEN-BINDING MOLECULES THAT BIND PSMA AND CD3, IN COMBINATION WITH COSTIMULATION 4-1BB |
2020 |
- Kirshner, Dzhessika R.
- Krouford, Elison
- Chiu, Danika
|
RU2822092C2 |
| NEW BISPECIFIC ANTIGEN-BINDING MOLECULES WITH CAPABILITY OF SPECIFICALLY BINDING TO CD40 AND FAP |
2018 |
- Bruenker Peter
- Bujotzek Alexander
- Duerr Harald
- George Guy
- Klein Christian
- Leclair Stephane
- Rapp Moritz
- Sum Eva Carina
- Trumpfheller Christine
- Umana Pablo
|
RU2766234C2 |
| METHOD AND COMPOSITIONS FOR CELL IMMUNOTHERAPY |
2013 |
- Jensen, Michael
- Riddell, Stanley, R.
- Hudecek, Michael
|
RU2700765C2 |
| BISPECIFIC ANTIBODIES TO CD25 AND Fc GAMMA-RECEPTOR FOR ELIMINATION OF TUMOR-SPECIFIC CELLS |
2017 |
- Kezada, Serkhio
- Peggs, Karl
- Arse Vargas, Frederik
|
RU2759970C2 |
| PHARMACEUTICAL COMPOSITION POSSESSING ANTITUMOUR EFFECT, AND METHOD FOR REDUCING PD-L1 INHIBITING EFFECT ON HUMAN T-CELLS |
2016 |
|
RU2688692C2 |
| PSCAXCD3, CD19XCD3, C-METXCD3, ENDOSIALIN XCD3, EPCAMXCD3, IGF-1RXCD3 OR FAP-ALPHA XCD3 BISPECIFIC SINGLE-CHAIN ANTIBODY WITH INTER-SPECIES SPECIFICITY |
2009 |
- Kufer,Peter
- Raum,Tobias
- Kischel,Roman
- Lutterbuse,Ralf
- Hoffmann,Patrick
- Rau,Doris
- Klinger,Matthias
- Mangold,Susanne
- Blumel,Claudia
|
RU2547600C2 |
