FIELD: biotechnology.
SUBSTANCE: disclosed is a kit containing a bispecific antibody molecule and material required for genetic transduction of CD8+T-cells, wherein the bispecific antibody molecule comprises a CD8+T-cell-transducing antigen binding domain, and a tumour-specific antigen binding domain. Also disclosed is use of a pharmaceutical composition containing said bispecific antibody molecule, in combination with genetically transduced CD8+T-cells for treating oncological disease and methods of treating oncological disease.
EFFECT: present invention provides targeted mobilization of CD8+T-cells into a tumour using bispecific antibody molecules that can be used in adoptive therapy.
29 cl, 24 dwg, 1 tbl, 5 ex
| Title |
Year |
Author |
Number |
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2017 |
|
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2020 |
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|
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2018 |
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- Umana Pablo
|
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| METHOD AND COMPOSITIONS FOR CELL IMMUNOTHERAPY |
2013 |
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- Hudecek, Michael
|
RU2700765C2 |
| BISPECIFIC ANTIBODIES TO CD25 AND Fc GAMMA-RECEPTOR FOR ELIMINATION OF TUMOR-SPECIFIC CELLS |
2017 |
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|
RU2759970C2 |
| PHARMACEUTICAL COMPOSITION POSSESSING ANTITUMOUR EFFECT, AND METHOD FOR REDUCING PD-L1 INHIBITING EFFECT ON HUMAN T-CELLS |
2016 |
|
RU2688692C2 |
| PSCAXCD3, CD19XCD3, C-METXCD3, ENDOSIALIN XCD3, EPCAMXCD3, IGF-1RXCD3 OR FAP-ALPHA XCD3 BISPECIFIC SINGLE-CHAIN ANTIBODY WITH INTER-SPECIES SPECIFICITY |
2009 |
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|
RU2547600C2 |
| MODIFIED MONOCYTES/MACROPHAGES EXPRESSING CHIMERIC ANTIGEN RECEPTORS AND THEIR APPLICATIONS |
2016 |
- Gill, Saar
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- June, Carl H.
|
RU2766690C2 |
