BISPECIFIC BINDING AGENTS FOR MODULATING BIOLOGICAL ACTIVITY Russian patent published in 2011 - IPC A61K39/395 C07K16/30 C07K16/18 A61P35/00

Abstract RU 2433831 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of medicine and deals with bispecific binding agents for modulating biological activity. Essence of invention includes bispecific binding agent, which is cable of directed action on cancer cells by means of binding domain with high affinity with respect to first marker of cell surface, which does not induce significant biological effect, and binding domain with low affinity, which specifically binds with second marker of cell surface, producing significant and required biological effect. Also claimed are pharmaceutical compositions for treatment of malignant tumour, their application for production of medication and sets for diagnostics and visualisation of tumour.

EFFECT: intensification of antitumor action.

37 cl, 7 ex, 2 tbl

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RU 2 433 831 C2

Authors

Nilsen Ulrik B.

Shoehberl' Birgit M.

Dates

2011-11-20—Published

2005-05-05—Filed