METHOD OF TREATING COMPENSATED AND DECOMPENSATED DISTURBED CARDIAC HEMODYNAMIC IN ACUTE VERAPAMIL POISONING Russian patent published in 2019 - IPC A61K33/06 A61K31/70 A61K31/46 A61K31/137 A61P9/00 A61P43/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine and aims at treating acute poisoning with verapamil. Variant of parameters disturbance (MAP, CI) of central hemodynamics is determined and medicinal agents are used according to the established version. With compensated: Calcium chloride, intravenously bolus 100 mg for 15 minutes followed by infusion introduction – 0.1–0.2 mg/kg; Atropine sulphate – 0.02 mg/kg; Dopamine – 10–12 mcg/kg/min; bolus Glucose – 0.5 g/kg for 15 minutes with subsequent infusion introduction – 0.25 g/kg/h; bolus Insulin – 1 unit/kg for 15 minutes with subsequent infusion introduction –1 units/kg/h, and with decompensated: Calcium chloride, intravenously bolus 200 mg for 15 minutes followed by infusion introduction – 0.1–0.2 mg/kg; Atropine sulphate – 0.02 mg/kg; Dopamine –12–15 mcg/kg/min; bolus Glucose – 0.25 g/kg for 15 minutes with subsequent infusion introduction – 0.25 g/kg/h; Norepinephrine – 0.02–0.05 mcg/kg/min; bolus Glucagon – 3 mg (30 mcg/kg) for 15 minutes with subsequent infusion introduction – 2–5 mg/h.

EFFECT: method provides reducing treatment duration of acute verapamil poisoning.

1 cl, 4 tbl, 2 ex