FIELD: medicine.
SUBSTANCE: present invention relates to immunology. Disclosed is an antibody and its antigen-binding entity capable of specific binding to the human T-cell receptor beta-chain TRBV9 segment. Also disclosed are nucleic acids, expression vectors, a method for producing a host cell, a host cell, a method for producing an antibody or an antigen-binding fragment thereof and pharmaceutical compositions. Disclosed is a method for inhibiting the biological activity of the T-cell receptor, a method of treating a disease or disorder mediated by a human T-cell receptor, and using the antibody or pharmaceutical composition.
EFFECT: present invention can find further application in therapy of various conditions, particularly celiac disease, T-cell leukemia and T-cell lymphoma.
32 cl, 5 dwg, 3 tbl, 7 ex
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Year |
Author |
Number |
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|
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|
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|
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|
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