METHOD OF DETERMINING BLOOD CONTENT OF RARE-EARTH ELEMENTS: YTTRIUM, LANTHANUM, CERIUM, PRASEODYMIUM, NEODYMIUM, SAMARIUM, EUROPIUM, GADOLINIUM, TERBIUM, DYSPROSIUM, HOLMIUM, ERBIUM, THULIUM, YTTERBIUM AND LUTETIUM BY MASS SPECTROMETRY WITH INDUCTIVELY COUPLED PLASMA Russian patent published in 2019 - IPC G01N33/49 

FIELD: medicine.

SUBSTANCE: invention refers to medicine and can be used to determine content of rare-earth elements (REE) in blood by inductively coupled plasma mass spectrometry. For this purpose, a solution of nitric acid is added to a blood sample, a solution of internal indium standard is heated and introduced into the sample. Rare earth elements are yttrium, lanthanum, cerium, praseodymium, neodymium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium and lutetium. Concentrated nitric acid with density of 1.415 g/cm³ is used. Mixture is heated for 25–30 minutes at temperature 65–70 °C. Add 0.05 cm³ internal standard solution with weight concentration of indium comparison element 1,000 mcg/dm³ and 4.45 cm³ 1 % nitric acid solution. Measurements are carried out in a reaction / collisional cell when helium is passed through it as a reactant gas at rate of 4.4 cm³/min. Content of specific REE is determined from a calibration curve.

EFFECT: invention increases sensitivity and accuracy of determining content REE in blood.

1 cl, 8 tbl