FIELD: medicine; pharmaceuticals.
SUBSTANCE: present invention relates to a method for producing K3 series vitamins, involving oxidation of starting 2-methylnaphthalene with compounds of hexavalent chromium in an acidic medium while heating to obtain 2-methyl-1,4-naphthoquinone (menadione) at the first step, reacting menadione with an aqueous solution of sodium bisulphite in a two-phase system consisting of an aqueous phase and an organic solvent, with crystallisation of menadione sodium bisulphite (MSB) at a second step, use of the mother solution after separation of MSB in reaction with nicotinamide during acidification to obtain MNB at the third stage. MSB solution before crystallisation is treated with a water-soluble aluminium compound in weight ratio of dry menadione to Al2O3 as 1:0.01–1 with subsequent alkalization of solution to pH 6.0 and separation of residue.
EFFECT: proposed method allows to obtain final products with a minimum chromium content.
1 cl, 4 ex
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