FIELD: organic chemistry, organic synthesis, chemical technology.
SUBSTANCE: invention relates to a method for synthesis of 2-methyl-1,4-naphthoquinone (menadione, vitamin K3) that is used broadly in medicinal practice and animal husbandry. Method for synthesis of 2-methyl-1,4-naphthoquinone involves oxidation of 2-methyl-1-naphthol with oxygen or oxygen-containing gas in medium of a low-polar or nonpolar organic solvent or in 2-methyl-1-naphthol melt at intensive stirring, under pressure 1 atm, not less, and temperature 20°C, not less. Method provides simplifying technology and preparing the end product of high purity and high yield.
EFFECT: improved preparing method.
4 cl, 1 tbl, 17 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF 2-METHYL-1,4-NAPTHOQUINONE OBTAINING | 2007 |
|
RU2365576C1 |
| METHOD OF PRODUCING SUBSTITUTED QUINONES | 2014 |
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RU2568645C1 |
| METHOD OF PRODUCING 2-METHYL-1,4-NAPHTHOQUINONE | 2009 |
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| METHOD OF SYNTHESIS OF SUBSTITUTED QUINONES, CATALYST FOR ITS REALIZATION AND METHOD OF CATALYST SYNTHESIS | 2001 |
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| METHOD FOR 2-METHYL-1,4-NAPHTHOQUINONE PRODUCTION | 2016 |
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| METHOD OF PREPARING 2-METHYL-1,4-NAPHTHOQUINONE AND CATALYST FOR CARRYING IT OUT | 2000 |
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| METHOD OF PRODUCING 2,6-DI-TERT-BUTYL-P-BENZOQUINONE | 2016 |
|
RU2654477C2 |
| 2-METHYL-1,4-NAPHTHOQUINONE PRODUCTION PROCESS | 1997 |
|
RU2142935C1 |
| PROCESS FOR PREPARING 2-METHYL-1,4-NAPHTHOQUINONE | 0 |
|
SU1121255A1 |
| METHOD OF 2-METHYL-1,4-NAPHTHOQUIN0NE SYNTHESIS | 1990 |
|
RU2022958C1 |
