NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWIS Russian patent published in 2019 - IPC A61K39/395 C12N15/13 C07K16/30 

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry. Described is a group of inventions comprising an isolated antibody or a functional fragment thereof which binds to a sialylated Lewis^a antigen, isolated polynucleotide coding a heavy chain of said antibody or its functional fragment, recovered polynucleotide encoding a light chain of said antibody or functional fragment thereof, a conjugate which binds to a sialylated Lewis^a antigen, containing said antibody or its functional fragment, a pharmaceutical composition for treating a disease, a method of treating or preventing a disease, wherein said disease is malignant or tumour formation with cells, expressing sialylated Lewes^a antigen, and a method for tumour detection in a patient, involving administering said conjugate.

EFFECT: invention extends range of agents for binding with sialylated Lewis^a antigen.

23 cl, 25 dwg, 12 tbl, 4 ex