COMBINED THERAPY BASED ON AFUCOSYLATED CD20 ANTIBODY IN COMBINATION WITH CD22 ANTIBODY CONJUGATE - DRUG PREPARATION Russian patent published in 2019 - IPC C07K16/28 A61K39/395 A61K45/06 A61K47/00 

Abstract RU 2700092 C2

FIELD: biotechnology.

SUBSTANCE: described is a combination of the obinutuzumab with a CD22 antibody-drug conjugate, which is anti-CD22-MC-vc-PAB-MMAE, for treating CD20 expressing cancer, wherein the anti-CD22 antibody in said conjugate contains a variable light chain domain of SEQ ID NO: 50 and heavy chain variable domain SEQ ID NO: 51.

EFFECT: invention extends the range of products for treating cancer, primarily a combination therapy for treating cancer types in which CD20 is expressed.

5 cl, 4 dwg, 6 tbl

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RU 2 700 092 C2

Authors

Klajn Kristian

Lang Zabine

Polson Endryu

Umana Pablo

Dates

2019-09-12Published

2014-04-30Filed