FIELD: biotechnology.
SUBSTANCE: described is a group of inventions involving a pharmaceutical combination for treating cancer wherein CD20 is expressed and using the pharmaceutical combination for preparing a drug for treating cancer wherein CD20 is expressed. Pharmaceutical combination consists of rituximab and BTK inhibitor, which is 6-amino-9-[(3R)-1-(2-butinoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one or a salt thereof, in a synergistically effective amount, where the amount of rituximab ranges from 0.1 to 50 mg/kg, and amount 6-amino-9-[(3R)-1-(2-butinoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one or its salt ranges from 1 mcg/kg to 50 mg/kg.
EFFECT: invention extends the range of agents for treating cancer in which CD20 is expressed.
5 cl, 5 dwg, 7 tbl, 3 ex
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