2-AMINOTHIAZOLE DERIVATIVE OR SALT THEREOF Russian patent published in 2019 - IPC C07D417/12 C07D417/14 A61K31/4439 A61K31/496 A61K31/506 A61P13/10 A61P13/02 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, where X is N, Y is CR^3e; R¹ and R² are combined with adjacent nitrogen atom to form cyclic amino, which can be substituted with C_1-6-alkyl, -OC_1-6-alkyl or C_3-8-cycloalkyl, and cyclic amino is azetidinyl, pyrrolidinyl, piperidinyl or piperazinyl; R^3a, R^3c, R^3d and R^3e are identical or different from each other and are H or halogen and R^3b is halogen-C_1-6-alkyl; R⁴ is H or halogen; R⁵ is H or C_1-6-alkyl; Q is a heterocyclyl which can be substituted with -C_1-6-alkylene-OC_1-6-alkyl, and heterocyclylene is piperidin-1,4-diyl or piperazine-1,4-diyl; W is C_1-6-alkylene or -OC_1-6-alkylene and n is 1. Invention also relates to a pharmaceutical composition having the activity of a positive allosteric regulator of muscarinic M₃-receptors containing an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient.

EFFECT: aminothiazole derivatives, which are a compound of formula (I), are intended for preventing or treating the urinary bladder/urinary tract diseases associated with bladder contractions caused by muscarinic M₃-receptors.

15 cl, 107 tbl, 56 ex