AMINOPYRIMIDINE DERIVATIVES AND USE THEREOF AS AROMATIC HYDROCARBON RECEPTOR MODULATORS Russian patent published in 2024 - IPC C07D239/42 C07D401/04 C07D401/14 C07D403/04 C07D403/14 A61K31/505 A61K31/506 A61K31/5377 A61P35/00 A61P37/00 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to a compound of formula (I) or its enantiomer, diastereomer, racemate, solvate, hydrate or pharmaceutically acceptable salt:

also relates to a compound selected from compounds 1–187 and 189–376, or an enantiomer, diastereomer, racemate, solvate, hydrate or pharmaceutically acceptable salt thereof, also relates to a pharmaceutical composition for preventing and/or treating a disease or condition mediated by an aromatic hydrocarbon receptor (AhR) and to a pharmaceutical composition for inhibiting proliferation, tissue invasion, metastasis and angiogenesis of malignant tumour cells in a subject with a malignant tumour or cancer condition, also relates to a method of modulating AhR activity in a subject, a method for preventing or treating a disease or condition mediated by an aromatic hydrocarbon receptor (AhR) in a subject, and a method for inhibiting proliferation, tissue invasion, metastasis and angiogenesis of cancer cells in a subject with a malignant tumour or cancer condition.

EFFECT: group of inventions provides the development of compounds which have selective inhibitory action on AhR.

24 cl, 2 tbl, 376 ex