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(19)

(11)

2 481 329

(13)

(51)

IPC

C07C311/21(2006-01-01)

C07D277/20(2006-01-01)

C07D277/36(2006-01-01)

C07D277/56(2006-01-01)

C07D417/12(2006-01-01)

C07D213/71(2006-01-01)

C07D401/12(2006-01-01)

C07D307/64(2006-01-01)

C07D405/12(2006-01-01)

A61K31/426(2006-01-01)

A61K31/427(2006-01-01)

A61K31/501(2006-01-01)

A61K31/506(2006-01-01)

A61K31/497(2006-01-01)

A61K31/4427(2006-01-01)

A61K31/4402(2006-01-01)

A61K31/4406(2006-01-01)

A61K31/4439(2006-01-01)

A61K31/63(2006-01-01)

A61K31/341(2006-01-01)

A61P13/00(2006-01-01)

(21) (22)

Application

2011102363/04, 2009-06-22

(24)

Start date

2009-06-22

(22)

Actual filing date

2009-06-22

(45)

Published

2013-05-10

(72)

Inventor

Kubota KhidekiTsukamoto IsseiKamidze KadzunoriKato KodziFukuda JutaAzami Khidenori

(73)

Holder

Astellas Farma Ink.

SULFONAMIDE COMPOUNDS AND SALTS THEREOF Russian patent published in 2013 - IPC C07C311/21 C07D277/20 C07D277/36 C07D277/56 C07D417/12 C07D213/71 C07D401/12 C07D307/64 C07D405/12 A61K31/426 A61K31/427 A61K31/501 A61K31/506 A61K31/497 A61K31/4427 A61K31/4402 A61K31/4406 A61K31/4439 A61K31/63 A61K31/341 A61P13/00

Abstract RU 2481329 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound selected from a group consisting of: 4-[(2-{[(2S)-2-fluoropropyl](pyridin-2-ylsulfonyl)amino}-4,5-dimethylphenoxy)methyl]benzoic acid, 4-[(2-{[(2R)-2-fluoropropyl](pyridin-2-ylsulfonyl)amino}-4,5-dimethylphenoxy)methyl]benzoic acid, 4-{[(6-{[(2R)-2-fluoropropyl](pyridin-2-ylsulfonyl)amino}-2,3-dihydro-1H-inden-5-yl)oxy)methyl} benzoic acid, 4-[(5-chlor-2-{[(2S)-2-fluoropropyl](pyridin-2-ylsulfonyl)amino}-4-methylphenoxy)methyl]benzoic acid, 4-[(5-chlor-2-{[(2R)-2-fluoropropyl](pyridin-2-ylsulfonyl)amino}-4-methylphenoxy)methyl]benzoic acid, 4-[(2-{[(2R)-3-fluor-2- methylpropyl](pyridin-2-ylsulfonyl)amino}-4,5-dimethylphenoxy)methyl]benzoic acid, 4-[(2-{[(2S)-3-fluor-2- methylpropyl](pyridin-2-ylsulfonyl)amino}-4,5-dimethylphenoxy)methyl]benzoic acid, 4-{[(6-{[(2R)-2-fluorobutyl](pyridin-2-ylsulfonyl)amino}-2,3-dihydro-1H-inden-5-yl)oxy)methyl} benzoic acid, 4-{[(6-{[(2S)-2-fluorobutyl](pyridin-2-ylsulfonyl)amino}-2,3-dihydro-1H-inden-5-yl)oxy)methyl}benzoic acid, 4-[(5-chlor-2-{[(2R)-2-fluoropropyl] (pyridin-3-ylsulfonyl)amino}-4-methylphenoxy)methyl]benzoic acid, 4-[(5-chlor- 2-{[(2S)-2-fluoropropyl](pyridin-3-ylsulfonyl)amino}-4-methylphenoxy)methyl] benzoic acid, 4-[(2-{[(2S)-2-fluoropropyl](pyridin-3-ylsulfonyl)amino}-4,5-dimethylphenoxy)methyl]benzoic acid, 4-[(2-{[(2R)-2-fluoropropyl](pyridin-3-ylsulfonyl)amino}-4,5-dimethylphenoxy)methyl] benzoic acid, 4-{[(6-{[(2S)-2-fluoropropyl](pyridin-3-ylsulfonyl)amino}-2,3-dihydro-1H-inden-5-yl)oxy)methyl} benzoic acid and 4-{[(6-{[(2R)-2-fluoropropyl](pyridin-3-ylsulfonyl)amino}-2,3-dihydro-1H-inden-5-yl)oxy)methyl}benzoic acid, or a pharmaceutically acceptable salt thereof. These compounds have an EP1 receptor antagonist effect and may be used for treating the dysfunction pollakiuria.

EFFECT: preparing the sulfonamide compounds with a strong EP1 receptor antagonist effect.

23 cl, 24 tbl, 31 ex

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RU 2 481 329 C2

Authors

Kubota Khideki

Tsukamoto Issei

Kamidze Kadzunori

Kato Kodzi

Fukuda Juta

Azami Khidenori

Dates

2013-05-10—Published

2009-06-22—Filed